JPL Nanotubes Help Advance Brain Tumor Research

MEDIA RELATIONS OFFICE
JET PROPULSION LABORATORY
CALIFORNIA INSTITUTE OF TECHNOLOGY
NATIONAL AERONAUTICS AND SPACE ADMINISTRATION
PASADENA, CALIF. 91109 TELEPHONE (818) 354-5011
http://www.jpl.nasa.gov

Rhea Borja (818) 354-0850
Jet Propulsion Laboratory, Pasadena, Calif.
Rhea.R.Borja@jpl.nasa.gov

Shawn Le (800) 888-5323
City of Hope, Duarte, Calif.
Sle@coh.org

NEWS RELEASE: 2008-006 Jan. 16, 2008

JPL Nanotubes Help Advance Brain Tumor Research

PASADENA, Calif.- The potential of carbon nanotubes to diagnose and treat brain tumors is
being explored through a partnership between NASA's Jet Propulsion Laboratory, Pasadena,
Calif., and City of Hope, a leading cancer research and treatment center in Duarte, Calif.

Nanotechnology may help revolutionize medicine in the future with its promise to play a role in
selective cancer therapy. City of Hope researchers hope to boost the brain's own immune
response against tumors by delivering cancer-fighting agents via nanotubes. A nanotube is about
50,000 times narrower than a human hair, but it length can extend up to several centimeters.

If nanotube technology can be effectively applied to brain tumors, it might also be used to treat
stroke, trauma, neurodegenerative disorders and other disease processes in the brain, said Dr.
Behnam Badie, City of Hope's director of neurosurgery and of its brain tumor program.

"I'm very optimistic of how this nanotechnology will work out," he said. "We are hoping to
begin testing in humans in about five years, and we have ideas about where to go next."

The Nano and Micro Systems Group at JPL, which has been researching nanotubes since about
2000, creates these tiny, cylindrical multi-walled carbon tubes for City of Hope.

City of Hope researchers, who began their quest in 2006, found good results: The nanotubes,
which they used on mice, were non-toxic in brain cells, did not change cell reproduction and
were capable of carrying DNA and siRNA, two types of molecules that encode genetic
information.

JPL's Nano and Micro Systems Group grows the nanotubes on silicon strips a few square
millimeters in area. The growth process forms them into hollow tubes as if by rolling sheets of
graphite-like carbon.

Carbon nanotubes are extremely strong, flexible, heat-resistant, and have very sharp tips.
Consequently, JPL uses nanotubes as field-emission cathodes -- vehicles that help produce
electrons -- for various space applications such as x-ray and mass spectroscopy instruments,
vacuum microelectronics and high-frequency communications.

"Nanotubes are important for miniaturizing spectroscopic instruments for space applications,
developing extreme environment electronics, as well as for remote sensing," said Harish
Manohara, the technical group supervisor for JPL's Nano and Micro Systems Group.

Nanotubes are a fairly new innovation, so they are not yet routinely used in current NASA
missions, he added. However, they may be used in gas-analysis or mineralogical instruments for
future missions to Mars, Venus and the Jupiter system.

JPL's collaboration with City of Hope began last year, after Manohara, Badie and Dr. Babak
Kateb, City of Hope's former director of research and development in the brain tumor program,
discussed using nanostructures to better diagnose and treat brain cancer. Badie said his team's
nanomedical research continues, and the next goal will be to functionalize and attach inhibitory
RNA to the nanotubes and deliver it to specific areas of the brain.

The JPL and City of Hope teams published the results of the study earlier this year in the journal
NeuroImage.

Badie says that JPL's contribution to City of Hope's nanomedicine research has been invaluable.

"The fact that we can get pristine and really clean nanotubes from Manohara's department is
unique," he said. "The fact that we are both collaborating for biological purposes is also really
unique."

The collaboration between JPL and City of Hope is conducted under NASA's Innovative
Partnership Program, designed to bring benefits of the space program to the public.

For more information about NASA's Innovative Partnership Programs, visit: www.ipp.nasa.gov .
For more information about City of Hope, visit: www.coh.org .

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